https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Evaluation of assumptions underpinning pharmacometric models https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46722 Tue 29 Nov 2022 11:20:34 AEDT ]]> A factor VII-based method for the prediction of anticoagulant response to warfarin https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33780 Tue 03 Sep 2019 18:01:49 AEST ]]> A joint model for vitamin K-dependent clotting factors and anticoagulation proteins https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31207 Emax model linked to a turnover model for coagulation proteins. In the joint model, an unexpected pharmacodynamic lag was identified and the estimated degradation half-life of VK-dependent coagulation proteins were in agreement with previously published values. The model provided an adequate fit to the observed data. Conclusion: The joint model represents the first work to quantify the influence of warfarin on all six VK-dependent coagulation proteins simultaneously. Future work will expand the model to predict the influence of exogenously administered VK on the time course of clotting factor concentrations after warfarin overdose and during perioperative warfarin reversal procedures.]]> Sat 24 Mar 2018 08:44:46 AEDT ]]>